FNDC5 relates to skeletal muscle IGF-I and mitochondrial function and gene expression in obese men with reduced growth hormone
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چکیده
منابع مشابه
Growth hormone and muscle function responses to skeletal muscle ischemia.
We examined the effects of ischemia (ISC) alone and with low-intensity exercise (ISC+EX) on growth hormone (GH) and muscle function responses. Nine men (22 +/- 0.7 yr) completed 3 study days: an ISC day (thigh cuff inflated five times, 5 min on, 3 min off), an ISC+EX day [knee extension at 20% maximal voluntary contraction (MVC) with ISC], and a control day. MVCs and submaximal contraction task...
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Human growth hormone (hGH) genomic sequence containing 5 exons and 4 introns was cloned in pcDNA-3 and the constructed plasmid was subsequently used for transfection ofNlli-3T3 cell line using lipofection technique. Expression of hGH in stably transfected cells was assayed using ELISA. Total RNA was extracted from transfected cells and hGH cDNA was amplified by RT-PCR using specific primers...
متن کاملTrKB and FNDC5 Gene Expression and SG6K1 Protein Response to Eccentric and Concentric Resistance Activity in Young Men
Background: The aim of the present study was to investigate the expression of TrKB, FNDC5 and SG6K1 protein in response to eccentric and concentric resistance training in healthy subjects. Methods: 10 healthy men were randomly assigned to two groups of concentric and eccentric contractions of 5 individuals each. Isokinetic contraction protocols included eccentric and concentric knee extension ...
متن کاملRegulation of muscle mass by growth hormone and IGF-I.
Growth hormone (GH) is widely used as a performance-enhancing drug. One of its best-characterized effects is increasing levels of circulating insulin-like growth factor I (IGF-I), which is primarily of hepatic origin. It also induces synthesis of IGF-I in most non-hepatic tissues. The effects of GH in promoting postnatal body growth are IGF-I dependent, but IGF-I-independent functions are begin...
متن کاملAre Heart Muscle Irisin Levels and FNDC5 Gene Expression Regulated by Endurance and Resistance Exercises?
Background. Irisin is the result of the proteolysis of fibronectin type III domain-containing protein 5, the levels of which are determined by physical activity. Objective(s). This study aims to identify changes in FNDC5 gene expression and the heart muscle irisin levels in male rats following 8 weeks resistance and endurance training. Methods. Fifteen male rats (10-12 weeks old and 331.8&plu...
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ژورنال
عنوان ژورنال: Growth Hormone & IGF Research
سال: 2016
ISSN: 1096-6374
DOI: 10.1016/j.ghir.2015.12.008